Conditions to Facilitate the Evolvability of Digital Proteins
نویسندگان
چکیده
A set of conditions is presented to enhance the evolvability of an arti cial core memory programming system. A digital protein (CPU) composed of a sequence of digital amino acids (instructions) is considered, and a set of implementation criteria is given to maximize the functionality and evolvability of proteins. Next, for a case study, we present the basic design of an ALife system named SeMar. The design of SeMar proteins (elementary instructions and a register architecture) is optimized considering the above conditions.
منابع مشابه
Protein dynamism and evolvability.
The traditional view that proteins possess absolute functional specificity and a single, fixed structure conflicts with their marked ability to adapt and evolve new functions and structures. We consider an alternative, "avant-garde view" in which proteins are conformationally dynamic and exhibit functional promiscuity. We surmise that these properties are the foundation stones of protein evolva...
متن کاملResolving the paradox of evolvability with learning theory: How evolution learns to improve evolvability on rugged fitness landscapes
It has been hypothesized that one of the main reasons evolution has been able to produce such impressive adaptations is because it has improved its own ability to evolve – “the evolution of evolvability”. Rupert Riedl, for example, an early pioneer of evolutionary developmental biology, suggested that the evolution of complex adaptations is facilitated by a developmental organization that is it...
متن کاملInvestigating the Function of Predicted Proteins from RNA-Seq Data in Holstein and Cholistani Cattle Breeds
This study was performed to determine the digital expression profile of different genes expressed in Holstein and Cholistani breeds as well as to evaluate the performance of predicted proteins derived from differentially expressed genes between these two breeds using RNA-Seq data. For this purpose, the whole mRNA sequence for a blood sample of American Holstein and Pakistani Cholistani cattle p...
متن کاملEvolvability is a selectable trait.
Concomitant with the evolution of biological diversity must have been the evolution of mechanisms that facilitate evolution, because of the essentially infinite complexity of protein sequence space. We describe how evolvability can be an object of Darwinian selection, emphasizing the collective nature of the process. We quantify our theory with computer simulations of protein evolution. These s...
متن کاملIn vitro study of drug-protein interaction using electronic absorption, fluorescence, and circular dichroism spectroscopy
In the near future, design of a new generation of drugs targeting proteins will be required. Considering the complex bond between the drug and protein, the structure and stability of the target protein should be considered. So far, a series of in vitro investigations have been conducted with the aim of predicting drug-biological medium interactions. In these studies, use of spectroscopic method...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2000